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Clinical Insights

Oclacitinib: Treating Pruritus and Beyond

For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus.

Clinical Insights

Grapiprant for Control of Osteoarthritis Pain in Dogs

For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used for pain control. However, their use has been associated with potentially life-threatening adverse drug events. Grapiprant is a novel drug for treatment of osteoarthritic pain in dogs. Approved in 2016, it is a non-cyclooxygenase (COX)-inhibiting NSAID.

Clinical Insights

Alfaxalone: An Old Drug in a New Formulation

Alfaxalone has been used to induce general anesthesia for many years, but only recently has a new formulation with preservatives become available in the United States. This formulation has a shelf life of 28 days after first use. It is approved for IV administration to induce and maintain general anesthesia in dogs and cats; however, it is also used via the IM route for induction and sedation (off label).

Clinical Insights

Pimobendan and Heart Disease

Pimobendan is a benzimidazole-pyridazinone derivative, labeled for use in dogs to manage congestive heart failure (CHF) resulting from dilated cardiomyopathy (DCM) or degenerative mitral valve disease (DMVD) in the United States. On the basis of its positive inotropic effects combined with arteriovenous dilation, it is classified as an inodilator.1 In this article, we provide relevant …

Clinical Insights

Ferret Distemper: What You Need to Know

Leonie Kondert, DVM Joerg Mayer, DVM, MS, DABVP, DACZM University of Georgia Distemper is an acute viral infectious disease with reported mortality rates in ferrets of 100%.1–5 Prevalence depends on the area, recent outbreaks have been documented in multiple countries.1,4 Since the invention of a vaccine against canine distemper virus (CDV) in the 1960s, the …

Clinical Insights

Leptospirosis

Leptospirosis is a bacterial disease that is of importance in human and veterinary medicine due to its zoonotic potential. With early and aggressive treatment that includes attentive monitoring, prognosis for recovery is excellent.

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