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Pharmacology

Grapiprant for Control of Osteoarthritis Pain in Dogs

For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used for pain control. However, their use has been associated with potentially life-threatening adverse drug events. Grapiprant is a novel drug for treatment of osteoarthritic pain in dogs. Approved in 2016, it is a non-cyclooxygenase (COX)-inhibiting NSAID.

Alfaxalone: An Old Drug in a New Formulation

Alfaxalone has been used to induce general anesthesia for many years, but only recently has a new formulation with preservatives become available in the United States. This formulation has a shelf life of 28 days after first use. It is approved for IV administration to induce and maintain general anesthesia in dogs and cats; however, it is also used via the IM route for induction and sedation (off label).

Mirtazapine in Cats: Dosage, Side Effects, and Efficacy

A closer look at the use of mirtazapine as an appetite stimulant in cats, including geriatric patients and those with kidney or liver disease.

A closer look at the use of mirtazapine as an appetite stimulant in cats, including dosage, side effects, and more.

monoclonal antibodies (mAbs)

The Therapeutic Power of Monoclonal Antibody Therapy

Biotherapeutics are still relatively new in veterinary medicine. This article reviews biologic therapy as it relates specifically to monoclonal antibodies (mAbs) and covers the only fully licensed and commercially available product, lokivetmab (Cytopoint).

Pimobendan and Heart Disease

Pimobendan is a benzimidazole-pyridazinone derivative, labeled for use in dogs to manage congestive heart failure (CHF) resulting from dilated cardiomyopathy (DCM) or degenerative mitral valve disease (DMVD) in the United States. On the basis of its positive inotropic effects combined with arteriovenous dilation, it is classified as an inodilator.1 In this article, we provide relevant …

Veterinary Behavior Medications: Which Medication, Which Patient?

At the core of state-of-the art multimodal treatment is smart, rational, and effective use of behavioral medication.

The best treatment approaches in veterinary behavioral medicine are often multimodal. At the core of state-of-the art multimodal treatment is smart, rational, and effective use of behavioral medication.

Use of Antibiotics for Treating UTIs in Dogs and Cats

Understanding drug pharmacokinetics and pharmacodynamics is essential when determining the most effective antibiotic therapy for UTIs in dogs and cats.

Most UTIs in dogs and cats are successfully treated with commonly used drugs, dosages, and administration intervals. However, infections can be challenging to effectively treat when they involve the kidneys (pyelonephritis) and prostate (prostatitis)…

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