Use of Acupuncture for Pain Management
Successful pain management encompasses pharmacologic and nonpharmacologic interventions. This is especially true for chronic, neuropathic, or persistent pain.1 While pharmacologic options remain the mainstays, nonpharmacologic interventions are an important part of a comprehensive pain management plan.
Acupuncture is a safe, nonpharmacologic intervention with minimal adverse effects that most animals tolerate well.2,3 It has become more accepted for pain relief in veterinary medicine. In fact, the pain management guidelines published by the American Animal Hospital Association, American Association of Feline Practitioners, and World Small Animal Veterinary Association endorse acupuncture as a safe adjunct treatment for pain management in dogs and cats that should be strongly considered as a part of a multimodal pain management regimen.4,5
Acupuncture can be used independently or integrated into conventional analgesia protocols. It has significant analgesic effects on inflammatory, neuropathic, cancer, and visceral pain states.6 It can help ease acute pain from neuromusculoskeletal injuries and surgery, as well as chronic spinal and osteoarthritic pain. Veterinary clinical trials also provide evidence for its effectiveness.2,7-20
HOW DOES ACUPUNCTURE WORK?
Acupuncture is the stimulation of certain points on the body that correspond to neurovascular bundles, blood plexuses, sites of nerve branching, and motor endplate zones (TABLE 1).21 Recent evidence suggests that the effects of acupuncture are likely mediated by the nervous system at peripheral, spinal, and supraspinal levels.6,22 Neurophysiologic effects of analgesia in response to acupoint stimulation include release of endogenous opioids and neurotransmitters (e.g., endorphin/endomorphin, enkephalin, 5-hydroxytryptamine), activation of the descending pain inhibitory pathway, and inhibition of inflammatory mediators (e.g., cyclooxygenase-2, interleukin-1β, interleukin-6).6,22 Acupuncture also causes micro-trauma and vasodilation to improve local circulation and catalyze healing.23 Recent evidence suggests inhibition of microglial activation by acupuncture may play a key role in neuropathic pain diseases.24
In 1 noncontrolled study, acupuncture alone or combined with analgesics reduced chronic pain and improved quality of life in dogs with neurologic and musculoskeletal diseases.8 Results were similar for acupuncture plus manual therapy in dogs with musculoskeletal pain; the authors found immediate short-term improvement in comfort level and mobility compared with before treatment.9
In 2 controlled studies in dogs with hip dysplasia, a gold bead implanted at acupoints significantly reduced osteoarthritic pain.10,11 A 2-year follow-up study revealed that gold-bead acupuncture provided long-term pain relief, an effect not observed in dogs receiving placebo.12
In another controlled study, neither acupuncture nor carprofen significantly differed from placebo on gait analysis of dogs with hip dysplasia, but only acupuncture was associated with a decrease in validated chronic pain scores.13 A controlled, blinded study in dogs undergoing hemilaminectomy found significantly lower postoperative pain scores in the acupuncture than the control group.14
Two studies showed that among cats undergoing ovariohysterectomy, the need for rescue analgesia after surgery was lower in the acupuncture than the control group.15,16 Similar results were found in dogs undergoing mastectomy.17
In horses, 2 controlled studies found acupuncture was effective in treating back pain.18,19 A recent study showed horses with chronic laminitis were improved by acupuncture after receiving 2 acupuncture treatments 1 week apart.20
METHODS OF STIMULATION
Acupoints can be stimulated by dry needle (DN), electroacupuncture (EA), aqua-acupuncture (AQ), laser acupuncture (LA), moxibustion, and material implantation (FIGURE 1).2,7 Each method traditionally serves a different purpose. DN involves the insertion of fine, sterile needles into acupoints. These needles vary in size (28- to 36-gauge) and length (0.25 to 1.5 inches). The needles are typically left in place for approximately 10 to 30 minutes.
In EA, acupoints are stimulated by applying electricity through needles for 10 to 30 minutes. EA has more profound and prolonged analgesic effects than other techniques.6 It is useful for neuralgia, nervous system injury, and persistent pain.6,7 Low-frequency EA (2 to 10 Hz) produces longer-lasting alleviation of inflammatory pain and inhibits nerve injury–related allodynia/hyperalgesia more potently than do higher frequencies (100 Hz).6
With AA, 0.1 to 0.5 mL of sterile fluid (e.g., saline, vitamin B12) is injected into acupoints. It is commonly used after DN or EA to prolong the effect of acupoint stimulation.
LA, the modern practice of stimulating acupoints using low-level energy of wavelengths (630 to 960 nm), may provide anti-inflammatory and antinociceptive effects.15
HOW IS ACUPUNCTURE INTEGRATED?
Veterinarians who have received formal training can incorporate acupuncture into conventional practice settings. Basic or advanced veterinary acupuncture courses are available at the Chi Institute of Traditional Chinese Veterinary Medicine, or through the International Veterinary Acupuncture Society.
Before acupuncture, underlying pain or medical conditions are always diagnosed as part of conventional care. Once standard treatment measures are underway, acupuncture can be used as an integrative modality to reduce acute or chronic pain. For outpatients, it can be offered at the clinic, once or twice a week. For inpatients, it can be performed in the hospital, once a day before discharge. Practices that do not offer acupuncture can refer patients to veterinarians with CVA (certified veterinary acupuncturist) credentials.
Veterinarians who perform acupuncture must obtain informed consent beforehand. The discussion of acupuncture in the context of conventional medicine must focus not only on the efficacy of acupuncture but also expectations and potential adverse effects. A multimodal approach with acupuncture may allow for a reduction in dose of conventional analgesics and therefore a decrease in their adverse effects.6 For patients that are resistant to pain medications or cannot tolerate their side effects, acupuncture can be a reasonable alternative treatment.
As with any therapy, not every patient responds to acupuncture; therefore, realistic expectations need to be set for clients. The author often requires clients to commit to sessions once or twice a week for at least 4 to 6 treatments, especially for chronic conditions. Although many patients may not need even 4 treatments to experience benefits, shorter durations and lower intensities of treatment may result in suboptimal outcomes. Acupuncture has both immediate and cumulative analgesic effects following repeated treatments.25
SAFETY AND CONTRAINDICATIONS
Acupuncture is safe when performed correctly by licensed veterinarians certified in veterinary acupuncture. Common minor adverse effects after acupuncture include tiredness, increased water intake, soreness, muscle spasm, and minor bleeding, which typically resolve quickly.2,3 Other rare complications include infection, dermatitis, and broken needle fragments. Acupuncture needles should not be placed on infected or inflamed skin, open wounds, or sites of tumor and fractures; around the abdomen of a pregnant animal; or in specific points that may contribute to premature parturition (i.e., ST-36, SP-6, BL-40, BL-60, and BL-67).2 Deep needle insertion into acupoints around the lung fields (e.g., SP-21, LIV-13, LIV-14, GB-24, BL-12 to BL-19) is contraindicated. Acupuncture should be used cautiously or avoided in patients with clotting abnormalities. Do not apply EA across the thorax area (heart position) in animals with heart disease or pacemakers.2 Be cautious when using acupoints around the eyes.
Case 1: Chronic Pain Associated With Polyarticular Osteoarthritis
A 13-year-old female spayed Weimaraner had osteoarthritis in multiple joints (elbows, carpi, hips, and stifles) and back pain. Despite the combination of firocoxib, gabapentin, tramadol, and glucosamine-chondroitin, her pain was worsening and her mobility was deteriorating. She developed urinary incontinence and was awoken more often during the night.
An internist suggested acupuncture as a last resort before euthanasia. The dog received acupuncture twice weekly for 4 weeks initially, then every 2 to 4 weeks. After 3 treatments, the dog could rise up and walk without assistance and sleep normally. Her urination incontinence was resolved after 6 treatments. She continued to receive acupuncture monthly for pain management. She died at home at age 16.
Her acupuncture treatment consisted of the following:
- DN: GV-20, TH-5, SI-9, GB-34, BL-40, LIV-3, Bai-hui
- EA: LI-4 to LI-11, ST-36 to ST-41, BL-11 bilaterally, BL-23 to Shen-shu (crossing), BL-54 bilaterally; 2 to 20 Hz for 20 minutes
- AA: TH-4, LU-5, LI-10, SI-9, BL-23, BL-54, ST-36, BL-39, KID-3; 0.1 to 0.2 mL per acupoint
Case 2: Pain and Neurologic Deficits Associated With Meningoencephalitis of Unknown Cause
A 4-year-old male neutered Yorkshire terrier was diagnosed with meningoencephalitis of unknown cause at the cervical region. He had nonambulatory tetraparesis with severe cervical pain and was hospitalized. He received IV fluids, immunosuppressive doses of dexamethasone, fentanyl constant rate infusion, cytosine arabinoside, and gabapentin. On day 4 of hospitalization, he was referred for acupuncture treatment. Despite medications, his neck was still severely painful on manipulation and he continued to have nonambulatory tetraparesis.
Shortly after his first acupuncture treatment, he could stand on his own unassisted and his cervical pain was markedly improved—he could move his neck without yelping. His fentanyl was discontinued the next day because of an improved pain level. The next day, after his second acupuncture, he became ambulatory on 4 limbs with minimal assistance. He continued to make significant progress over the next 3 days with daily acupuncture. On day 7, he had full range of motion of his neck and was ambulatory with mild ataxia.
His acupuncture treatment consisted of the following:
- DN: GV-20, LU-7, SI-3, LI-4, LIV-3, ST-36, Jing-jia-ji
- EA: GV-16 to Bai-hui, GB-20 to GB-21 (crossing), BL-23 bilaterally, PC-8 bilaterally, KID-1 bilaterally; 2 to 20 Hz for 20 minutes
- AA: Jing-jia-ji, GV-14, Liu-feng; 0.1-0.2cc per acupoint
Given the low risk for adverse effects and observed benefits for acute and chronic pain, acupuncture can play a large role in pain management and can be incorporated into veterinary practice as part of a multimodal approach. With the increasing number of clinical trials and laboratory research, we better understand the mechanism of action and therapeutic effects of acupuncture. Nonetheless, larger randomized controlled trials are needed to verify its efficacy in veterinary medicine.
- World Association of Traditional Chinese Veterinary Medicine (AATCVM): watcvm.org
- American Academy of Veterinary Acupuncture (AAVA): aava.org
- American Holistic Veterinary Medical Association (AHVMA): ahvma.org
- National Center for Complementary and Integrative Health (NCCIH): nccih.nih.gov
- Xie’s Veterinary Acupuncture, 1st ed.
- Veterinary Acupuncture: Ancient Art to Modern Medicine, 2nd ed.
- Greene SA. Chronic pain: pathophysiology and treatment implications. Top Companion Anim Med 2010;25(1):5-9.
- Fry LM, Neary SM, Sharrock J, Rychel JK. Acupuncture for analgesia in veterinary medicine. Top Companion Ani Med 2014;29:35-42.
- le Jeune S, Henneman K, May K. Acupuncture and equine rehabilitation. Vet Clin North Am Equine Pract 2016;32(1):73-85.
- Epstein M, Rodan I, Griffenhagen G, et al. 2015 AAHA/AAFP pain management guidelines for dogs and cats. JAAHA 2015;2:67-84.
- Mathews K, Kronen PW, Lascelles D, et al. Guidelines for recognition, assessment and treatment of pain: WSAVA global pain council members and co-authors of this document. J Small Anim Pract 2014;55:E10-E68.
- Zhang R, Lao L, Ren K, Berman BM. Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology 2014;120(2):482-503.
- Roynard P, Frank L, Xie H, Fowler M. Acupuncture for small animal neurologic disorders. Vet Clin North Am Small Anim Pract 2018 Jan;48(1):201-219.
- Silva NEOF, Luna SPL, Joaquim JGF, et al. Effect of acupuncture on pain and quality of life in canine neurological and musculoskeletal diseases. Can Vet J 2017;58(9):941-951.
- Lane DM, Hill SA. Effectiveness of combined acupuncture and manual therapy relative to no treatment for canine musculoskeletal pain. Can Vet J 2016;57(4):407-414.
- Jaeger GT, Larsen S, Søli N, Moe L. Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia. Vet Rec 2006;158(21):722-726.
- Hielm-Björkman A, Raekallio M, Kuusela E, et al. Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia. Vet Rec 2001;149:452-456.
- Jæger GT, Larsen S, Søli N, et al. Two years follow-up study of the pain-relieving effect of gold bead implantation in dogs with hip-joint arthritis. Acta Vet Scand 2007;49:1-7.
- Teixeira LR, Luna SP, Matsubara LM, at al. Owner assessment of chronic pain intensity and results of gait analysis of dogs with hip dysplasia treated with acupuncture. JAVMA 2016;249(9):1031-1039.
- Laim A, Jaggy A, Forterre F, et al. Effects of adjunct electroacupuncture on severity of postoperative pain in dogs undergoing hemilaminectomy because of acute thoracolumbar intervertebral disk disease. JAVMA 2009;234(9):1141-1146.
- Marques VI, Cassu RN, Nascimento FF, et al. Laser acupuncture for postoperative pain management in cats. Evid Based Complement Alternat Med 2015;2015:653270.
- Ribeiro MR, de Carvalho CB, Pereira RHZ, et al. Yamamoto new scalp acupuncture for postoperative pain management in cats undergoing ovariohysterectomy. Vet Anaesthes Analges 2017;44(5):1236-1244.
- Gakiya HH, Silva DA, Gomes J, et al. Electro-acupuncture versus morphine for the postoperative control pain in dogs. Acta Cir Bras 2011;26:346e351.
- Xie H, Colahan P, Ott EA. Evaluation of electroacupuncture treatment of horses with signs of chronic thoracolumbar pain. JAVMA 2005;227(2):281-286.
- Rungsri P, Trinarong C, Rojanasthien S, et al. Effectiveness of electro-acupuncture on pain threshold in sport horses with back pain. Am J Trad Chinese Vet Med 2009;4:22-26.
- Faramarzi B, Lee D, May K, Dong F. Response to acupuncture treatment in horses with chronic laminitis. Can Vet J 2017;58(8):823-827.
- Zhou F, Huang D, Ying X. Neuroanatomic basis of acupuncture points. In: Xia Y, Cao X, Wu G, Cheng J (eds). Acupuncture Therapy for Neurological Diseases. Berlin: Springer; 2010:32-80.
- Lin JG, Chen WL. Acupuncture analgesia: a review of its mechanisms of actions. Am J Chin Med 2008:36(4):635-645.
- Lundeberg T. Peripheral effects of sensory nerve stimulation (acupuncture) in inflammation and ischemia. Scand J Rehabil Med 1993;29:61-86.
- Lin L, Skakavac N, Lin X, et al. Acupuncture-induced analgesia: the role of microglial inhibition. Cell Transplant 2016;25(4):621-628.
- Xiang A, Cheng K, Shen L. The immediate analgesic effect of acupuncture for pain: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2017:3837194.