Elizabeth Huynh, DVM, is a diagnostic imaging resident and graduate student at University of Florida College of Veterinary Medicine. Her interests include ultrasonography, cross-sectional imaging, and nuclear medicine. She received her DVM from Ross University, finished her clinical year at Ohio State University, and completed a diagnostic imaging internship at Animal Specialty and Emergency Center in Los Angeles, California.Read Articles Written by Elizabeth Huynh
Clifford R. Berry
Dr. Berry is an adjunct professor of diagnostic imaging at the University of Florida and a clinical assistant professor of diagnostic imaging at North Carolina State University College of Veterinary Medicine. He received his DVM from University of Florida and completed a radiology residency at University of California–Davis. He has a specific interest in diagnostic imaging of the thorax.
Updated October 2022Read Articles Written by Clifford R. Berry
Welcome to our series of articles on small animal abdominal ultrasonography. The initial articles provided an overview of basic ultrasonography principles and a discussion about how to perform a systematic scan of the abdomen. The rest of the series discusses ultrasound evaluation of specific abdominal organs/systems.
Localization and Scanning Technique
The pancreas is a lobulated, thin, elongated organ that is divided into three parts: the right lobe, the left lobe, and the body. It is one of the most difficult structures to identify in the normal patient due to the similar echogenicity and echostructure of the pancreas and the adjacent mesentery and fat.
Recognition of normal anatomic landmarks is key to finding the normal pancreas and should allow, at minimum, visualization of the region of where the pancreas should be located if one cannot directly visualize the pancreas itself. There are anatomic differences between the dog and the cat.1
Patients with pancreatitis often have significant cranial abdominal pain and resist the pressure of the transducer that is necessary to image the region. Therefore, appropriate sedation and analgesics should be considered to improve image quality and diagnostic accuracy.
The right lobe is the largest lobe in the dog and extends caudally and parallel to the descending duodenum. This lobe can be evaluated using a ventral or lateral approach. When using the ventral approach, place the transducer medial to the right 13th rib and angle dorsally and cranially to get the right kidney in long axis. Next, angle medially to find the descending duodenum. Moving the transducer medial to the descending duodenum will allow one to identify the location of the right lobe of the pancreas (FIGURE 1).
In the dog, the pancreaticoduodenal vein can be an anatomic landmark for the right lobe of the pancreas adjacent to the duodenum. To image the right lobe in cross section, first the duodenum is imaged in long axis, the transducer is then rotated 90 degrees to obtain a cross section of the duodenum, and the right lobe will be visible as a triangular structure immediately adjacent to the duodenum (FIGURE 2).
In the cat, the right lobe extends along the descending duodenum and then hooks back on itself (FIGURE 3). The right lobe of the pancreas and the descending duodenum are closer to a midline position when compared to the dog.
The left lobe extends to the left of midline, near the cranial pole of the left kidney, but rarely to the level of the splenic hilum in the dog. The left lobe is closely associated with the greater curvature of the stomach and found in a region bound cranially by the stomach, caudally by the transverse colon, and, in the near field, by the body of the spleen; it is closely associated with the splenic portal vasculature (FIGURE 4).
In the cat, the left lobe of the pancreas is larger than the right lobe and extends to the left close to the splenic hilum (FIGURE 5).
The body is located where the right and left lobes come together, immediately ventral to the portal vein and common bile duct. Occasionally, the pancreatic duct is seen as two thin hyperechoic lines that are 1 mm apart in the center of the pancreas.1,2
In the cat, the body of the pancreas and the pyloroduodenal junction are in a more midline position (Figure 6).
Normal Ultrasonographic Features
Adequate ultrasound imaging of the pancreas is highly dependent upon the ultrasonographer’s skills and knowledge of the regional anatomy. The pancreas is an elongated organ that is localized by using various anatomic structures: the body is located at the pyloroduodenal junction, immediately ventral to the portal vein; the left lobe is caudal to the greater curvature of the stomach; and the right lobe is located in the mesoduodenum in the dog (FIGURE 7).1-5
Patient factors also play a role in ultrasound imaging. Excessive aerophagia and inadequate fasting often result in significant shadowing and reverberation artifacts from the gastric contents. These artifacts will likely obscure the region of the left lobe and body of the pancreas, making assessment of these structures challenging or impossible, particularly in dogs.
The normal pancreas, if visualized, is isoechoic to slightly hypoechoic to the surrounding mesentery. The boundaries of the pancreas are delineated by thin hyperechoic lines.
The normal canine pancreas is 6 to 8 mm thick with a pancreatic ductal diameter of 0.6 mm. The normal feline pancreas is 4 to 6 mm thick with a pancreatic ductal diameter of 1 mm.
As cats age, the pancreatic ductal diameter can measure up to 2.5 mm without evidence of pancreatic disease (FIGURE 8).
Additionally, in older cats − and to a lesser extent, dogs − nodular hyperplasia can be present with focal hypoechoic nodules (3−10 mm) being noted within the pancreas (FIGURE 9).3,4
Occasionally, a pancreas can be diffusely hyperechoic but still measure within normal limits for thickness (FIGURES 1 and 7). Histopathology in dogs with a hyperechoic pancreas has been normal to fibrotic from what was believed to be prior pancreatitis.
The most common abnormality of the canine and feline pancreas is pancreatitis. Pancreatitis can have a variety of ultrasound abnormalities depending upon the severity, extent, and duration of the pancreatic and peripancreatic changes.1 Detection of pancreatitis on ultrasound may be difficult as the pancreas can appear ultrasonographically normal. A normal appearing pancreas does not rule out pancreatitis.
In acute pancreatitis, the pancreas can become enlarged, hypoechoic, and rounded or irregularly marginated. The surrounding mesenteric fat is hyperechoic and hyperattenuating, and there is often mild to moderate collections of echogenic effusion in the area of the inflamed pancreas (FIGURE 10), representing peritonitis and/or fat saponification. Fat saponification is also known as steatitis.
Saponification of the peripancreatic mesenteric fat may be present as a result of the release of pancreatic enzymes locally and may cause multifocal areas of dystrophic mineralization around the pancreas, forming small hyperechoic shadowing structures (FIGURE 11).1
The duodenum and/or stomach wall can be thickened due to secondary inflammation of this area. A focal paralytic ileus and corrugation of the duodenum can be present (FIGURE 12). In these patients, the wall layers will be altered but there will not be total loss of wall layering as seen in neoplastic processes of the stomach and duodenum. Rarely, the colon (ascending or transverse) can be involved.
In some dogs and cats, the ultrasound findings lag behind clinical signs, and the initial ultrasound may be normal. Conversely, recheck ultrasound scans can document persistent severe changes while, clinically, the patient is doing better and is back on a feeding regimen.
Additionally, pancreatitis can be incited by a pancreatic mass, therefore, a recheck evaluation 2 weeks following pancreatitis may be useful in older patients to evaluate for pancreatic neoplasia.6
Pancreatitis in cats has been reported in conjunction with hepatic lipidosis, inflammatory bowel disease, and cholangiohepatitis. This concomitant presence of inflammatory bowel disease and cholangiohepatitis with pancreatitis is a common pathologic entity in cats called feline triaditis; the intestinal tract and liver should be carefully scrutinized for concurrent abnormalities in cats with pancreatitis.1
In cases of necrotizing pancreatitis, hypo- to anechoic regions of hemorrhage and necrosis can be seen. One can use color or power Doppler to assess for blood flow in areas of the pancreas that are affected, in order to rule out necrotizing pancreatitis, although motion artifacts often make accurate color Doppler examination challenging in these patients with cranial abdominal pain.
Possible sequelae to pancreatitis include pancreatic cysts (retention cysts or pseudocysts) or abscesses. Pancreatic cystic lesions typically form rounded, anechoic structures associated with distal enhancement artifact; however, it is not possible to differentiate between congenital cysts, pseudocysts secondary to cavitation from pancreatitis, and retention cysts secondary to ductal obstruction.
The appearance of a pancreatic abscess is similar to that of other intraabdominal abscesses. Abscesses are associated with distal acoustic shadowing but may, in addition, have a thick, irregular wall associated with perilesional inflammation (markedly hyperechoic fat and effusion) and may also show reverberation artifact from gas producing bacteria.
Another common sequela of pancreatitis is extrahepatic obstruction of the common bile duct, resulting in dilation of the common bile duct, cystic duct, gallbladder, and eventually extra- and intrahepatic biliary ducts (FIGURE 13).
In the case of chronic pancreatitis, the pancreas can be hyperechoic or heterogeneous (hyper- and hypoechoic areas) and thickened with peripancreatic inflammatory changes. One can see pancreatic ductal dilation in cats with chronic pancreatitis, although as mentioned above, age-related dilation is commonly seen in older cats.
Noninflammatory Pancreatic Edema
In dogs and cats with hypoalbuminemia or portal hypertension, edema of the pancreas can be present. Edema fluid in the interlobular septae of the pancreas appears ultrasonographically as multiple anechoic areas that divide the gland, resulting in a distinctive tiger-stripe appearance.7
It may be difficult to differentiate pancreatic neoplasia from abscesses, necrosis, and acute pancreatitis.
Pancreatic neoplasia can arise from either the exocrine (eg, adenocarcinoma) or endocrine (eg, beta cell tumors or insulinomas) portion.8
Differentiation between pancreatic neoplasia and nodular hyperplasia may be difficult as they have similar ultrasonographic findings. However, a single lesion exceeding 2 cm in diameter is more likely to be neoplastic, whereas nodular hyperplasia typically forms multiple, smaller hypoechoic nodules.1
Adenocarcinomas form hypoechoic or heterogeneous pancreatic masses without evidence of peripancreatic inflammation. These tumors have been shown to develop within the body of the pancreas; they can compress the bile duct, invade adjacent gastrointestinal structures, and have frequent metastases to the liver (there the nodules may be target-like in appearance, with a hypoechoic rim and iso- to hyperechoic center). The mass(es) may have dystrophic mineralization associated with the tumor.
Signs of malignancy of pancreatic neoplasms include lymphadenopathy and metastasis to other abdominal organs or to the mesentery and peritoneal surfaces (ie, carcinomatosis). In the case of carcinomatosis, hypoechoic nodules will be seen along the parietal and visceral peritoneal surfaces (FIGURE 14). Cats with pancreatic carcinomatosis, will often present with a distended abdomen due to a significant effusion.
Other tumor types that have been reported in dogs and cats include cystadenoma, metastatic carcinoma, and lymphoma.
Although rare, endocrine tumors (eg, insulinoma) occur as hypoechoic nodules to masses within the pancreatic parenchyma. By the time of insulinoma diagnosis, metastasis has often already occurred, and careful examination of the regional lymph nodes and liver is necessary in these cases to identify metastatic lesions. Lymph nodes with metastases will be enlarged and hypoechoic. As with pancreatic carcinoma, insulinoma metastases may form hypoechoic or target-like lesions in the hepatic parenchyma (FIGURE 15).
A systematic examination of the pancreas based on normal anatomy is a routine part of the complete abdominal ultrasound evaluation. Common pancreatic abnormalities in the dog and cat may not be immediately apparent on ultrasonography, therefore, recheck ultrasound scans or other diagnostics may be indicated in some patients.
- Penninck DG, d’Anjou M. Atlas of Small Animal Ultrasonography. 2nd ed. Ames: Wiley Blackwell; 2015.
- Penninck DG, Zeyen U, Taeymans O, Webster CR. Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs. Am J Vet Res 2013;74(3):433-437.
- Hecht S, Penninck DG, Keating JH. Imaging findings in pancreatic neoplasia and nodular hyperplasia in 19 cats. Vet Radiol Ultrasound 2007;48(1):45-50.
- Larson MM, Panciera DL, Ward DL, et al. Age-related changes in the ultrasound appearance of the normal feline pancreas. Vet Radiol Ultrasound 2005;46(3):138-142.
- Etue SM, Penninck DG, Labato MA, et al. Ultrasonography of the normal feline pancreas and associated anatomical landmarks: a prospective study of 20 cats. Vet Radiol Ultrasound 2001;42(4):330-336.
- Edwards DF, Bauer MS, Walker MA, et al. Pancreatic masses in seven dogs following acute pancreatitis. J Am Anim Hosp Assoc 1990;26(2):189-198.
- Lamb CR. Pancreatic edema in dogs with hypoalbuminemia and portal hypertension. J Vet Intern Med 1999;13(5):498-500.
- Lamb CR, Simpson KW, Boswood A, Matthewman LA. Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. Vet Rec 1995;137(3):65-68.